Abstract: Surgical Treatment for Clusters of Calcified Breast Lesions in 143 Patients withoutBreast LumpsJinhai TANG1, Kaihua ZHAO2, Xiaoming XU1, Yiqin HU1, Qiao YU1, Minghua JI1, Jianping GONG1, Jianwei QIN1Correspondence to: Jinhai TANG, E-mail: sdwfzkh@163.com1Breast Surgical Department, Jiangsu Provincial Tumor Hospital, Nanjing 210009, China2Surgery Department, Xuzhou Medical College, Xuzhou 221004, ChinaThis work was supported by The Health Research Projects of Jiangsu Province (No. H200930)Abstract Objective: To study the surgical treatment for clusters of calcified breast lesions in 143 patients without breast lumps.Methods: One hundred and forty-three patients with clusters of calcified areas based on mammography with neither palpable mass normass identifiable by radiography were preliminarily diagnosed with early stage breast cancer. Such a diagnosis was determined basedon the malignant calcification foci shown by radiography with full field digital mammography (FFDM) performed in Jiangsu ProvincialTumor Hospital. Coordinate orientation was conducted, then accurate localization and excision were performed, and finally FFDMre-examination was done. Patients with single lesions received breast-conserving surgery, and the cancer lesion was excised preciselywith the aid of preoperative localization by FFDM coordinate orientation. Breast reconstruction was accomplished synchronously usingwide-based gland-tissue flap stageⅠbreast reconstruction. The patients with multiple lesions underwent modified radical mastectomy.Results: Seventeen patients had atypical ductal hyperplasia, 15 patients had ductal carcinoma in situ, and 111 patients had malignant le-sions. Two patients with ductal carcinoma underwent simple mastectomy, and 13 patients underwent lesion resection and local postoper-ative radiotherapy. Of the patients with malignant tumors, 88 underwent breast-conserving surgery. The accuracy of localization forthis procedure was 100% (88/88). Single focus lesions were excised completely with negative margins according to FFDM and patho-logical examination. The rate of successful mammoplasty was 88.1% (89/101). The 23 patients with extramammary diffuse calcified fo-ci underwent modified radical mastectomy. During the follow-up period of 6 to 61 months (average time of 40 months), distant metasta-sis occurred in 2 patients and no local recurrence was observed. Conclusion: After lesion localization of a single calcification focus inthe breast, breast-conserving surgery followed by synchronous wide-based gland-tissue flap stageⅠbreast reconstruction is recommend-ed as a minimally invasive surgery for its simplicity, minimal invasion and the end product of a fairly well-shaped breast.Keywords Breast neoplasm; Mastectomy; Segment; Mammaplasty